Necroptosis: a specialized pathway of programmed necrosis

Cell. 2008 Dec 26;135(7):1161-3. doi: 10.1016/j.cell.2008.12.004.


Necrosis is often viewed as an accidental and unregulated cellular event. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by regulated mechanisms. Hitomi et al. (2008) now describe an extensive network of genes that mediate a form of programmed necrosis called necroptosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis*
  • Humans
  • Necrosis*
  • Signal Transduction*