Mitofusin 2 builds a bridge between ER and mitochondria

Cell. 2008 Dec 26;135(7):1165-7. doi: 10.1016/j.cell.2008.12.005.


Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axonal Transport
  • Cell Line
  • Endoplasmic Reticulum / metabolism*
  • GTP Phosphohydrolases / metabolism*
  • Mice
  • Mitochondria / metabolism*
  • Purkinje Cells / metabolism


  • GTP Phosphohydrolases
  • Mfn1 protein, mouse
  • Mfn2 protein, mouse