IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines

FEBS Lett. 2009 Jan 22;583(2):259-65. doi: 10.1016/j.febslet.2008.12.030. Epub 2008 Dec 25.


Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / metabolism*
  • Breast Neoplasms / etiology
  • Breast Neoplasms / metabolism*
  • Female
  • Humans
  • Interleukin-1 / metabolism*
  • Leptin / metabolism*
  • Obesity / complications
  • Obesity / metabolism


  • Adipokines
  • Interleukin-1
  • Leptin