Brain-derived neurotrophic factor, stress and depression: a minireview

Brain Res Bull. 2009 Mar 30;78(6):267-9. doi: 10.1016/j.brainresbull.2008.12.002. Epub 2008 Dec 26.


Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression are rapidly replicating. Considering the data that stress plays an important role by the development of depression which is characterized with prominent hippocampal cell death, as well as the well known neuroprotective effects of BDNF, we aimed to investigate the link between the BDNF, stress and depression. Thus we prepared a minireview in order to evaluate the neuroprotective role of BDNF by psychiatric disorders which are characterized with prominent neuronal cell death.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor / genetics
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Cell Death
  • Depressive Disorder, Major / genetics
  • Depressive Disorder, Major / metabolism*
  • Genetic Predisposition to Disease
  • Humans
  • Neurons / physiology
  • Neuroprotective Agents / metabolism
  • Stress, Physiological*


  • Brain-Derived Neurotrophic Factor
  • Neuroprotective Agents