We conducted this retrospective study to identify the most appropriate oral antibiotic as empiric treatment of urinary tract infection according to resistance patterns of uropathogens among children treated at Queen Alia Military Hospital and Prince Aisha Bent Al-Hussein Military Center from January 2006 to April 2007. Urine cultures for isolated microorganism and their anti-biotic susceptibility in patients below the age of 14 years treated as outpatient were reviewed. Out of 3820 cultures, 529 isolates were found, E coli was the most frequent organism. Resistance to Ampicillin, sulfamethoxazole, and trimethoprim (TMP-SMZ) was common, and multidrug-resistant (MDR) among E. coli isolates was 59.9%. Knowledge of patterns of resistance at each institution helps in deciding empiric therapy for UTI. Pretreatment urine culture should be performed and followed up for the continuation of the treatment.