Evaluating signatures of sex-specific processes in the human genome

Nat Genet. 2009 Jan;41(1):8-10. doi: 10.1038/ng0109-8.


Comparing levels of genetic variation between the X chromosome and autosomes can reveal the different demographic histories of males and females of a species. Taking this approach, two new studies report that the effective population sizes of men and women differ, but they disagree as to which sex outnumbered the other.

Publication types

  • Comment
  • News

MeSH terms

  • Africa
  • Chromosomes, Human, X / genetics*
  • Emigration and Immigration
  • Evolution, Molecular
  • Female
  • Genetic Drift
  • Genetic Variation
  • Genome, Human / genetics*
  • Humans
  • Male
  • Selection, Genetic
  • Sex Characteristics*
  • Sex Ratio