Zoonotic vaccinia virus: clinical and immunological characteristics in a naturally infected patient

Clin Infect Dis. 2009 Feb 1;48(3):e37-40. doi: 10.1086/595856.

Abstract

Vaccinia virus was used as vaccine to eradicate smallpox. We report a zoonotic case of vaccinia virus infection in a 30-year-old patient who became infected after handling sick dairy cattle. The patient had inflamed lesions and systemic symptoms. Laboratory findings were indicative of down-modulated immune responses to the virus.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Cattle
  • Cattle Diseases / transmission*
  • Cattle Diseases / virology*
  • Cells, Cultured
  • Humans
  • Interferon-gamma / metabolism
  • Leukocytes, Mononuclear / immunology
  • Male
  • Skin / pathology
  • Vaccinia / diagnosis*
  • Vaccinia / immunology
  • Vaccinia / veterinary*
  • Vaccinia virus / immunology
  • Vaccinia virus / isolation & purification*
  • Zoonoses / transmission*
  • Zoonoses / virology*

Substances

  • Interferon-gamma