Literature-curated protein interaction datasets

Nat Methods. 2009 Jan;6(1):39-46. doi: 10.1038/nmeth.1284.


High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Databases, Factual
  • Databases, Protein*
  • Humans
  • Protein Binding
  • Proteins / analysis
  • Proteins / chemistry
  • Proteins / metabolism*
  • Reproducibility of Results
  • Research Design


  • Proteins