Abstract
Six new ambuic acid (1) derivatives (2-7) and a new torreyanic acid analogue (8) have been isolated from the crude extract of endophytic fungus Pestalotiopsis sp. inhabiting the lichen Multiclavula [corrected] sp. The structures of these compounds were elucidated primarily by NMR and MS methods, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1 and 2 displayed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ascomycota / chemistry*
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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China
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Cyclohexanones / chemistry
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Cyclohexanones / isolation & purification*
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Cyclohexanones / pharmacology
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Epoxy Compounds / chemistry
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Epoxy Compounds / isolation & purification*
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Epoxy Compounds / pharmacology
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Escherichia coli / drug effects
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Geotrichum / drug effects
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Lichens / microbiology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Quinones / chemistry
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Quinones / isolation & purification*
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Quinones / pharmacology
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Cyclohexanones
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Epoxy Compounds
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Quinones
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ambuic acid
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torreyanic acid