Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp

J Nat Prod. 2009 Jan;72(1):182-6. doi: 10.1021/np800733y.

Abstract

Six new ambuic acid (1) derivatives (2-7) and a new torreyanic acid analogue (8) have been isolated from the crude extract of endophytic fungus Pestalotiopsis sp. inhabiting the lichen Multiclavula [corrected] sp. The structures of these compounds were elucidated primarily by NMR and MS methods, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1 and 2 displayed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / chemistry*
  • Aspergillus fumigatus / drug effects
  • Candida albicans / drug effects
  • China
  • Cyclohexanones / chemistry
  • Cyclohexanones / isolation & purification*
  • Cyclohexanones / pharmacology
  • Epoxy Compounds / chemistry
  • Epoxy Compounds / isolation & purification*
  • Epoxy Compounds / pharmacology
  • Escherichia coli / drug effects
  • Geotrichum / drug effects
  • Lichens / microbiology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Quinones / chemistry
  • Quinones / isolation & purification*
  • Quinones / pharmacology
  • Staphylococcus aureus / drug effects
  • Streptococcus pneumoniae / drug effects

Substances

  • Cyclohexanones
  • Epoxy Compounds
  • Quinones
  • ambuic acid
  • torreyanic acid