Antidepressants on trial: how valid is the evidence?

Br J Psychiatry. 2009 Jan;194(1):1-3. doi: 10.1192/bjp.bp.108.054767.


A recent meta-analysis concluded that newer antidepressant drugs are equivalent to or no better than placebos, a conclusion at some variance with their commonly judged clinical effectiveness. The 'disconnect' between randomised controlled trials and clinical practice would benefit from dissection of contributing factors, and redressing limitations to current trial procedures.

Publication types

  • Editorial

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Depressive Disorder / drug therapy*
  • Humans
  • Models, Psychological
  • Placebo Effect
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index


  • Antidepressive Agents