Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds

J Am Vet Med Assoc. 2009 Jan 1;234(1):81-7. doi: 10.2460/javma.234.1.81.

Abstract

Objective: To evaluate the effectiveness and safety of cefovecin sodium in the treatment of cats with naturally occurring skin infections (abscesses and infected wounds).

Design: Multicenter (26 sites), randomized, double-blind, controlled clinical trial.

Animals: Client-owned cats of any breed with naturally occurring skin infections with associated clinical signs and confirmatory bacteriologic culture results.

Procedures: Cats with clinical signs of skin and soft tissue infection were randomly allocated to receive a single dose of cefovecin (8 mg/kg [3.6 mg/lb], SC) followed by placebo drops administered orally once daily for 14 days or 1 SC placebo injection followed by cefadroxil (22 mg/kg [10 mg/lb], PO, once daily for 14 days). Only one 14-day treatment course was permitted.

Results: Effectiveness of cefovecin in the treatment of cats with abscesses and infected wounds was similar to that of cefadroxil. At the final assessment on day 28, 97% (86/89) of cefovecin-treated cats and 91% (80/88) of cefadroxil-treated cats were considered treatment successes. There were no serious adverse events or deaths related to treatment.

Conclusions and clinical relevance: 1 SC injection of 8 mg of cefovecin/kg for the treatment of cats with naturally occurring skin infections (wounds and abscesses) was safe and as effective as cefadroxil administered orally at 22 mg/kg, once daily for 14 days.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Abscess / drug therapy
  • Abscess / veterinary*
  • Administration, Oral
  • Animals
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Cat Diseases / drug therapy*
  • Cats
  • Cephalosporins / adverse effects
  • Cephalosporins / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Injections, Subcutaneous / veterinary
  • Male
  • Microbial Sensitivity Tests / veterinary
  • Safety
  • Treatment Outcome
  • Wound Infection / drug therapy
  • Wound Infection / veterinary*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • cefovecin