Antibiotic clearance of Ehrlichia canis from dogs infected by intravenous inoculation of carrier blood

Ann N Y Acad Sci. 2008 Dec;1149:263-9. doi: 10.1196/annals.1428.087.


Ehrlichia canis is the etiologic agent of canine monocytic ehrlichiosis (CME) and is a useful model for zoonotic tick-borne pathogens, many of which infect dogs. The purpose of this study was to evaluate rifampin and doxycycline regimens for clearance of E. canis infections in addition to alleviation of CME. Beagles were infected with E. canis by intravenous inoculation with carrier blood and treated with either rifampin or doxycycline after the acute phase of CME. Improved hematological values demonstrated that both treatments effectively relieved signs of the disease. Peripheral blood from all dogs became PCR negative after antibiotic treatment, suggesting that these infections were eliminated and that rifampin is an effective alternative chemotherapeutic agent for treatment of CME.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Dog Diseases / blood
  • Dog Diseases / transmission*
  • Dogs
  • Doxycycline / pharmacokinetics*
  • Ehrlichia canis / metabolism*
  • Ehrlichiosis / blood
  • Ehrlichiosis / transmission*
  • Female
  • Rifampin / pharmacokinetics*


  • Doxycycline
  • Rifampin