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, 19 (3), 654-7

The Synthesis and Structure-Activity Relationship of Substituted N-phenyl Anthranilic Acid Analogs as Amyloid Aggregation Inhibitors

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The Synthesis and Structure-Activity Relationship of Substituted N-phenyl Anthranilic Acid Analogs as Amyloid Aggregation Inhibitors

Lloyd J Simons et al. Bioorg Med Chem Lett.

Abstract

It is believed that beta-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify beta-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for beta-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.

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