Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

Nat Med. 2009 Jan;15(1):31-3. doi: 10.1038/nm.1902. Epub 2009 Jan 4.


Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / therapeutic use
  • Biomarkers, Pharmacological / metabolism
  • Cells, Cultured
  • Down-Regulation / genetics
  • Drug Resistance, Viral / genetics
  • Hepatitis C / drug therapy*
  • Hepatitis C / genetics
  • Hepatitis C / metabolism
  • Hepatitis C / pathology
  • Humans
  • Interferon-alpha / therapeutic use*
  • Liver / metabolism
  • Liver / pathology
  • Liver / virology
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Treatment Failure
  • Viral Load


  • Antiviral Agents
  • Biomarkers, Pharmacological
  • Interferon-alpha
  • MIRN122 microRNA, human
  • MicroRNAs