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Review
. 2009 Feb;10(2):148-55.
doi: 10.1038/nrm2617. Epub 2008 Dec 24.

Mechanisms of regulated unconventional protein secretion

Walter Nickel  1 , Catherine Rabouille
Affiliations
Review

Mechanisms of regulated unconventional protein secretion

Walter Nickel et al. Nat Rev Mol Cell Biol. 2009 Feb.

Erratum in

  • Nat Rev Mol Cell Biol. 2009 Mar;10(3):234

Abstract

Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.

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