Wnt signaling in eye organogenesis

Organogenesis. 2008 Apr;4(2):60-7. doi: 10.4161/org.4.2.5850.


The vertebrate eye consists of multiple tissues with distinct embryonic origins. To ensure formation of the eye as a functional organ, development of ocular tissues must be precisely coordinated. Besides intrinsic regulators, several extracellular pathways have been shown to participate in controlling critical steps during eye development. Many components of Wnt/Frizzled signaling pathways are expressed in developing ocular tissues, and substantial progress has been made in the past few years in understanding their function during vertebrate eye development. Here, I summarize recent work using functional experiments to elucidate the roles of Wnt/Frizzled pathways during development of ocular tissues in different vertebrates.

Keywords: Wnt; chick; ciliary body; eye; frizzled; frog; lens; mouse; retina; vasculature; zebrafish.