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Clinical Trial
. 1991;45(2-3):121-4.
doi: 10.1016/0753-3322(91)90132-d.

Prospective Randomized Controlled Study on Bestatin in Resectable Gastric Cancer

Affiliations
Clinical Trial

Prospective Randomized Controlled Study on Bestatin in Resectable Gastric Cancer

M Niimoto et al. Biomed Pharmacother. .

Abstract

The efficacy of Bestatin as adjuvant immunochemotherapy in patients with resectable gastric cancer was investigated. Ninety-six patients with similar background factors were randomized into 2 groups: a control group and an experimental group, the patients in the latter group receiving a daily oral dose of 60 mg Bestatin over a long period. All 96 patients were treated with a bolus intravenous injection of mitomycin C (MMC) plus oral administration of tegafur (FT-207, FT). The survival rate of the patients in the MMC+FT+Bestatin group was more favorable than that of the patients in the MMC+FT group, but the difference was not statistically significant. The survival rates of the MMC+FT+Bestatin group patients in the stratification of stage III+IV and positive histological serosal invasion, ps(+), were significantly superior to those of the MMC+FT group patients (Logrank test: p less than 0.05). Moreover, in patients with positive histological serosal invasion, the recurrence of peritoneal dissemination was significantly suppressed in the MMC+FT+Bestatin group.

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