Coronary artery calcium scoring on low-dose prospective electrocardiographically-triggered 64-slice CT

Acad Radiol. 2009 Feb;16(2):187-93. doi: 10.1016/j.acra.2008.05.017.


Rationale and objectives: The purpose of this prospective study was to assess image noise and variability in repeated coronary artery calcium (CAC) scoring on low-dose prospective electrocardiographically-triggered 64-slice multidetector computed tomography.

Materials and methods: Patients (n = 115) suspected of having coronary artery disease were scanned twice, using a tube current of 10 x body mass index mA. The standard deviation (SD) of the computed tomographic value in the ascending aorta and (mean + 2 x SD) were obtained. Repeated CAC scores (Agatston, volume, and mass) were measured by two observers, and the interscan and interobserver variability were determined.

Results: The mean tube current used was 246 +/- 36 mA. The mean tube current-time product and mean estimated effective dose were 57 +/- 8 mA and 0.9 +/- 0.2 mSv, respectively. The SD and (mean + 2 x SD) computed tomographic values in the ascending aorta were 16 +/- 3 and 75 +/- 10 Hounsfield units, respectively. Repeated CAC scores were correlated (r(2) = 0.995-0.998). The interscan variability for observer 1 and observer 2, respectively, were 13% and 13% for Agatston score, 12% and 11% for volume, and 11% and 11% for mass. The interobserver variability for scan 1 and scan 2, respectively, were 3% and 3% for Agatston score, 5% and 3% for volume, and 3% and 3% for mass.

Conclusion: Low-dose prospective electrocardiographically-triggered 64-slice multidetector computed tomography shows low interscan and interobserver variability on CAC scoring while maintaining low image noise.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Calcinosis / diagnostic imaging*
  • Coronary Angiography / methods*
  • Coronary Artery Disease / diagnostic imaging*
  • Electrocardiography / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radiation Dosage
  • Radiographic Image Enhancement / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*