[Intravenous thrombolysis with rt-PA in stroke: experience of the Nice stroke unit]

Rev Neurol (Paris). 2009 May;165(5):471-8. doi: 10.1016/j.neurol.2008.10.023. Epub 2009 Jan 4.
[Article in French]


Introduction: Intravenous thrombolysis with rt-Pa in stroke has been approved in France since 2002. We report an evaluation of our practice. We have tried to identify predictive factors of dependence and death, and to compare our results with the data of the literature.

Patients and method: All patients treated with intravenous rt-PA within the first 270min after the stroke onset were included. Univariate, then multivariate analyses were performed to determine the variables influencing the functional outcome at 3 months follow-up, according to a dichotomy established from the modified Rankin scale.

Results: One hundred and forty-two patients were included in this study (mean initial National Institute of Health Stroke Scale [NIHSS]: 15). Fifty percent had a Rankin score higher than 2 at 3 months follow-up. NIHSS above 12, glycemia of at least 120mg/l, and systolic blood pressure above 160mmHg at admission were identified as independent predictive factors of poor functional outcome. Less than 4 points decrease of NIHSS proved to be a simple and early predictor of poor functional outcome at 3 months follow-up.

Conclusions: In terms of safety and efficacy the data issuing from the daily activity of our stroke unit are comparable with those of clinical trials.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Clinical Trials as Topic
  • Female
  • Fibrinolytic Agents / therapeutic use*
  • France
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Safety
  • Stroke / drug therapy*
  • Tissue Plasminogen Activator / administration & dosage
  • Tissue Plasminogen Activator / therapeutic use*


  • Fibrinolytic Agents
  • Tissue Plasminogen Activator