Interventions to improve inpatient osteoporosis management following first osteoporotic fracture: the PREVENT project

Arch Orthop Trauma Surg. 2009 Feb;129(2):245-50. doi: 10.1007/s00402-008-0809-1. Epub 2009 Jan 6.


Objectives: To establish a protocol for the treatment of fragility fractures in the hospital setting based on treatment of osteoporosis.

Materials and methods: An intervention protocol was implemented in patients with fragility fractures based on (1) indicating the diagnosis of osteoporotic fracture in the summary of discharge; (2) "lifestyle recommendations"; and (3) therapy for osteoporosis. Thirty-one hospitals were involved and they were informed of the importance of protocol compliance. In the first phase, a retrospective study was conducted to establish the number of low-energy fractures treated and the percentage of them that had complied with the protocol (n = 887). Then, prospectively, the same data were collected for the patients managed for 1 year (n = 6,826) in three sections of 4-month intervals.

Results: The percentage of compliance increased from 8.2 to 57.2% in the first point, from 12.6 to 42.4% in the second, and from 10.3 to 43.2% in the third.

Conclusion: The implementation of programs to improve osteoporosis treatment is very useful for ensuring adherence in the management of osteoporosis following admission due to fragility fracture.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Ambulatory Care
  • Bone Density Conservation Agents / administration & dosage*
  • Calcitonin / administration & dosage
  • Calcium / administration & dosage
  • Clinical Protocols
  • Diphosphonates / administration & dosage
  • Female
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / therapy*
  • Guideline Adherence
  • Hospitalization
  • Humans
  • Male
  • Osteoporosis / complications
  • Osteoporosis / drug therapy*
  • Osteoporosis / therapy
  • Prospective Studies
  • Retrospective Studies
  • Vitamin D / administration & dosage


  • Bone Density Conservation Agents
  • Diphosphonates
  • Vitamin D
  • Calcitonin
  • Calcium