In Leishmaniasis Due to Leishmania Guyanensis Infection, Distinct Intralesional interleukin-10 and Foxp3 mRNA Expression Are Associated With Unresponsiveness to Treatment

J Infect Dis. 2009 Feb 15;199(4):576-9. doi: 10.1086/596508.

Abstract

The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antiprotozoal Agents / therapeutic use*
  • Female
  • Forkhead Transcription Factors / genetics*
  • Forkhead Transcription Factors / metabolism
  • Gene Expression Regulation
  • Humans
  • Interleukin-10 / genetics*
  • Interleukin-10 / metabolism
  • Leishmania guyanensis / drug effects*
  • Leishmaniasis, Cutaneous / drug therapy*
  • Leishmaniasis, Cutaneous / immunology
  • Leishmaniasis, Cutaneous / parasitology
  • Male
  • Middle Aged
  • Pentamidine / therapeutic use*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism
  • Treatment Failure

Substances

  • Antiprotozoal Agents
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • RNA, Messenger
  • Interleukin-10
  • Pentamidine