There is an association between contact allergy to aluminium and persistent subcutaneous nodules in children undergoing hyposensitization therapy

Contact Dermatitis. 2009 Jan;60(1):41-9. doi: 10.1111/j.1600-0536.2008.01474.x.

Abstract

Background: The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules.

Objectives: To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine if there is any association between persistent subcutaneous nodules and aluminium allergy.

Patients/methods: Sixty-one children with allergic asthma and/or allergic rhinitis participated in the study of whom 37 had had hyposensitization therapy. The study consisted of a non-clinical part based on a questionnaire and a clinical part with a physical examination, self-assessment of itching, and patch testing. To secure an unbiased evaluation of possible reactions, the investigators were blinded.

Results: Contact allergy to aluminium was found in eight participants, all in the exposed group (8/37 versus 0/24, P = 0.02). Examination showed nodules on the upper arms in 13 participants, all in the group exposed to hyposensitization therapy. Nodules were over-represented in patients with contact allergy to aluminium.

Conclusions: There was a statistically significant association between contact allergy to aluminium and persistent subcutaneous nodules in children who had had hyposensitization therapy.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Age Distribution
  • Aluminum / adverse effects*
  • Chi-Square Distribution
  • Child
  • Comorbidity
  • Cross-Sectional Studies
  • Dermatitis, Allergic Contact / epidemiology*
  • Dermatitis, Allergic Contact / immunology
  • Dermatitis, Allergic Contact / therapy*
  • Desensitization, Immunologic / adverse effects*
  • Desensitization, Immunologic / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Hypersensitivity / epidemiology
  • Hypersensitivity / etiology
  • Hypersensitivity / pathology
  • Incidence
  • Male
  • Patch Tests / adverse effects*
  • Probability
  • Pruritus / chemically induced
  • Pruritus / epidemiology*
  • Pruritus / pathology
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Sex Distribution
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Young Adult

Substances

  • Aluminum