Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies

Molecules. 2009 Jan 1;14(1):174-90. doi: 10.3390/molecules14010174.

Abstract

Transition metal complexes of Co(II), Ni(II) and Cu(II) metal ions with general stoichiometry [M(L)X]X and [M(L)SO(4)], where M = Co(II), Ni(II) and Cu(II), L = 3,3'-thiodipropionic acid bis(4-amino-5-ethylimino-2,3-dimethyl-1-phenyl-3-pyrazoline) and X = NO(3)(-), Cl(-) and OAc(-), have been synthesized and structurally characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV and EPR. The nickel(II) complexes were found to have octahedral geometry, whereas cobalt(II) and copper(II) complexes were of tetragonal geometry. The covalency factor (beta) and orbital reduction factor (k) suggest the covalent nature of the complexes. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi, i.e. Alternaria brassicae, Aspergillus niger and Fusarium oxysporum and two bacteria, i.e. Xanthomonas compestris and Pseudomonas aeruginosa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternaria / drug effects
  • Ampyrone / analogs & derivatives*
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Aspergillus niger / drug effects
  • Cobalt / chemistry
  • Copper / chemistry
  • Electron Spin Resonance Spectroscopy
  • Fusarium / drug effects
  • Nickel / chemistry
  • Propionates / chemistry*
  • Pseudomonas aeruginosa / drug effects
  • Pyrazoles / chemistry*
  • Schiff Bases / chemistry
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Xanthomonas / drug effects

Substances

  • 3,3'-thiodipropionic acid bis(4-amino-5-ethylimino-2,3-dimethyl-1-phenyl-3-pyrazoline)
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Propionates
  • Pyrazoles
  • Schiff Bases
  • Ampyrone
  • Cobalt
  • Copper
  • Nickel