What causes cell death in Parkinson's disease?

Ann Neurol. 2008 Dec;64 Suppl 2(0 2):S3-15. doi: 10.1002/ana.21573.


Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death / genetics*
  • Cell Death / physiology
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Mutation
  • Neuroprotective Agents / therapeutic use
  • Parkinson Disease / genetics*
  • Parkinson Disease / pathology*
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy
  • Protein-Serine-Threonine Kinases / genetics
  • alpha-Synuclein / genetics


  • Neuroprotective Agents
  • alpha-Synuclein
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein-Serine-Threonine Kinases