Clinical immunology review series: An approach to the management of pulmonary disease in primary antibody deficiency

Clin Exp Immunol. 2009 Feb;155(2):147-55. doi: 10.1111/j.1365-2249.2008.03851.x.


The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.

Publication types

  • Review

MeSH terms

  • Bronchiectasis / complications
  • Bronchiectasis / therapy
  • Humans
  • Immunologic Deficiency Syndromes / complications
  • Immunologic Deficiency Syndromes / diagnosis
  • Immunologic Deficiency Syndromes / therapy*
  • Lung Diseases / diagnosis
  • Lung Diseases / therapy*
  • Opportunistic Infections / complications
  • Opportunistic Infections / therapy
  • Pneumonia / complications
  • Pneumonia / therapy
  • Tomography, X-Ray Computed