Mechanisms of analgesia by gabapentin and pregabalin--calcium channel alpha2-delta [Cavalpha2-delta] ligands

Pain. 2009 Mar;142(1-2):13-6. doi: 10.1016/j.pain.2008.11.019. Epub 2009 Jan 6.
No abstract available

Publication types

  • Review

MeSH terms

  • Amines / pharmacology
  • Amines / therapeutic use
  • Analgesics / pharmacology
  • Analgesics / therapeutic use
  • Animals
  • Calcium Channels / metabolism*
  • Cell Adhesion / physiology
  • Cyclohexanecarboxylic Acids / pharmacology
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Gabapentin
  • Humans
  • Models, Biological
  • Pregabalin
  • Protein Binding / drug effects
  • Protein Transport / physiology
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • gamma-Aminobutyric Acid / analogs & derivatives
  • gamma-Aminobutyric Acid / metabolism
  • gamma-Aminobutyric Acid / pharmacology
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Amines
  • Analgesics
  • CACNA2D1 protein, human
  • Calcium Channels
  • Cyclohexanecarboxylic Acids
  • Pregabalin
  • gamma-Aminobutyric Acid
  • Gabapentin