Tuberous sclerosis complex with unilateral perisylvian polymicrogyria and contralateral hippocampal sclerosis - a case report

Seizure. 2009 May;18(4):303-5. doi: 10.1016/j.seizure.2008.11.005. Epub 2009 Jan 6.


Malformations of cortical development (MCD) encompass a wide spectrum of brain disorders. Although rare, the combination of certain MCD may occur. We report a rare case of combination of three distinct cerebral pathologies: tuberous sclerosis, polymicrogyria and hippocampal sclerosis in a patient with intractable epilepsy. Ictal EEG and ictal SPECT suggested right perisylvian area as a seizure onset zone. However, on MRI multiple potentially epileptogenic lesions were identified. The neurobiological background of the coexistence of different types of malformations of cortical development remains enigmatic.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Cortex / abnormalities*
  • Cerebral Cortex / diagnostic imaging
  • Electroencephalography / methods
  • Female
  • Hippocampus / diagnostic imaging
  • Hippocampus / pathology*
  • Humans
  • Magnetic Field Therapy
  • Malformations of Cortical Development / complications*
  • Malformations of Cortical Development / diagnostic imaging
  • Tomography, Emission-Computed, Single-Photon / methods
  • Tuberous Sclerosis / complications*
  • Tuberous Sclerosis / diagnostic imaging
  • Young Adult