Crossing barriers: infections of the lung and the gut

Mucosal Immunol. 2009 Mar;2(2):100-2. doi: 10.1038/mi.2008.79. Epub 2008 Dec 24.

Abstract

Although known as respiratory pathogens, severe acute respiratory syndrome (SARS) and its sister coronaviruses frequently cause enteric symptoms. In addition, other classically non-enteric viruses (such as HIV and influenza) may also have enteric effects that are crucial in their pathogeneses. These effects can be due to direct infection of the gut mucosa, but can also be because of decreased antibacterial defenses, increased mucosal permeability, bacterial translocation, and systemic leak of endotoxin.

Publication types

  • Comment

MeSH terms

  • Bacterial Infections / complications
  • Bacterial Infections / microbiology
  • Bacterial Infections / virology
  • Coronavirus / metabolism
  • Coronavirus Infections / complications
  • Coronavirus Infections / microbiology
  • Coronavirus Infections / virology*
  • Enteritis / complications
  • Enteritis / microbiology
  • Enteritis / virology
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / virology*
  • HIV Infections / complications
  • HIV Infections / microbiology
  • HIV Infections / virology
  • HIV-1 / metabolism
  • Humans
  • Influenza, Human / complications
  • Influenza, Human / microbiology
  • Influenza, Human / virology
  • Lung / microbiology
  • Lung / virology*
  • Peyer's Patches / microbiology
  • Peyer's Patches / virology*
  • SARS Virus / metabolism
  • Severe Acute Respiratory Syndrome / complications
  • Severe Acute Respiratory Syndrome / microbiology
  • Severe Acute Respiratory Syndrome / virology