Oxidase-like activity of polymer-coated cerium oxide nanoparticles

Angew Chem Int Ed Engl. 2009;48(13):2308-12. doi: 10.1002/anie.200805279.


Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cell Line, Tumor
  • Cerium / chemistry*
  • Fluorescent Dyes / chemistry
  • Humans
  • Kinetics
  • Metal Nanoparticles / chemistry*
  • Oxidation-Reduction
  • Oxidoreductases / metabolism
  • Polymers / chemistry*


  • Fluorescent Dyes
  • Polymers
  • Cerium
  • ceric oxide
  • Oxidoreductases