A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion

Brain Res. 1991 Jun 14;551(1-2):308-10. doi: 10.1016/0006-8993(91)90946-s.


The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.

MeSH terms

  • Administration, Oral
  • Animals
  • Conditioning, Psychological*
  • Dopamine / metabolism*
  • Extracellular Space / metabolism*
  • Male
  • Nucleus Accumbens / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Saccharin / pharmacology
  • Stimulation, Chemical
  • Taste / physiology*


  • Saccharin
  • Dopamine