Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use

Trends Pharmacol Sci. 2009 Feb;30(2):61-5. doi: 10.1016/j.tips.2008.11.003. Epub 2009 Jan 8.

Abstract

Adult hippocampal stem/progenitor cells (AHPs) continuously give rise to new neurons throughout life, which might be an important determinant of hippocampus-dependent function. Strikingly, the fate potential of AHPs is not restricted to the neuronal lineage because AHPs can be genetically induced to generate oligodendrocytes within their in vivo niche by AHP-specific ectopic expression of the basic-helix-loop-helix (bHLH) transcription factor achaete-scute complex-like 1 (ASCL1). Fate plasticity of AHPs is controlled by cell-autonomous and also niche-dependent mechanisms. Here, we discuss the biological importance and potential therapeutic applications of retained fate plasticity of AHPs in the adult mammalian brain in addition to the future scientific inquiries indicated by this finding.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / cytology
  • Adult Stem Cells / physiology*
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / physiology
  • Cell Differentiation
  • Cell Lineage
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Humans
  • Neuronal Plasticity*
  • Neurons / cytology
  • Neurons / physiology*
  • Oligodendroglia / cytology
  • Oligodendroglia / metabolism

Substances

  • Basic Helix-Loop-Helix Transcription Factors