Rotavirus-associated encephalopathy with a reversible splenial lesion

Pediatr Neurol. 2009 Feb;40(2):131-3. doi: 10.1016/j.pediatrneurol.2008.10.015.


The case is reported of a 2-year-old boy with a rotavirus-induced mild encephalopathy that presented as transient intensified signal on the splenium of the corpus callosum. The boy also experienced persistent diarrhea, vomiting, fever, and sudden disturbance of consciousness. Although cerebrospinal fluid analysis did not manifest pleocytosis, electroencephalography demonstrated global diffuse slow waves and cranial magnetic resonance imaging demonstrated intensified signal on the splenium of the corpus callosum. Methylprednisolone was infused for 3 days. The disturbance of consciousness disappeared within 24 hours without any other complications, and the splenial signal and electroencephalogram returned to normal within 6 days.

Publication types

  • Case Reports

MeSH terms

  • Brain Diseases / drug therapy
  • Brain Diseases / etiology*
  • Brain Diseases / pathology
  • Child, Preschool
  • Consciousness Disorders / drug therapy
  • Corpus Callosum* / pathology
  • Corpus Callosum* / physiopathology
  • Diffusion Magnetic Resonance Imaging
  • Electroencephalography
  • Humans
  • Leukocytosis / cerebrospinal fluid
  • Leukocytosis / drug therapy
  • Male
  • Methylprednisolone / therapeutic use
  • Midazolam / therapeutic use
  • Rotavirus Infections / complications*
  • Rotavirus Infections / drug therapy
  • Rotavirus Infections / physiopathology


  • Midazolam
  • Methylprednisolone