Host Defense and Pathogenesis in Staphylococcus Aureus Infections

Infect Dis Clin North Am. 2009 Mar;23(1):17-34. doi: 10.1016/j.idc.2008.10.003.


Staphylococcus aureus is the most abundant cause of bacterial infections in the United States. As such, the pathogen has devised means to circumvent destruction by the innate immune system. Neutrophils are a critical component of innate immunity and the primary cellular defense against S aureus infections. This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Humans
  • Neutrophils / immunology
  • Staphylococcal Infections / immunology*
  • Staphylococcal Infections / pathology*
  • Staphylococcus aureus / immunology*
  • Staphylococcus aureus / pathogenicity*
  • Virulence
  • Virulence Factors / physiology


  • Virulence Factors