Cytogenetic evaluation of 20 cultured primary prostatic tumors

Cancer Genet Cytogenet. 1991 Aug;55(1):79-84. doi: 10.1016/0165-4608(91)90238-p.


We report the cytogenetic evaluation of 20 cultured cell strains derived from primary prostatic adenocarcinomas obtained from radical prostatectomies. The majority of the strains contained cells with only normal male karyotypes (46,XY), but cytogenetically abnormal clonal populations were found in five strains. Two of those strains contained aberrations involving the Y chromosome, one with a -Y and one with a +Y. Three strains (one of which also had the XYY karyotype) exhibited cells with double-minute chromosomes and four strains contained near tetraploid cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Chromosome Banding
  • Humans
  • Karyotyping
  • Male
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Sex Chromosome Aberrations*
  • Tumor Cells, Cultured
  • Y Chromosome*