[Optimisation of the antibiotic policy in the Netherlands. XII. The SWAB guideline for antimicrobial eradication of MRSA in carriers]

Ned Tijdschr Geneeskd. 2008 Dec 6;152(49):2667-71.
[Article in Dutch]

Abstract

The 'Stichting Werkgroep Antibioticabeleid' (SWAB; Dutch Working Party on Antibiotics Policy) has developed evidence-based guidelines for the antimicrobial treatment of methicillin-resistant Staphylococcus aureus (MRSA) carriers for the eradication of MRSA. A distinction was made between uncomplicated and complicated carriage depending on the presence or absence of an active MRSA infection, skin lesions, foreign body material, mupirocin resistance and/or extranasal carriage. The indication for treatment is determined by the consequences of carriage for the carrier and his/her environment, the adverse events of treatment, and the likelihood of a successful treatment. The first choice of treatment in uncomplicated carriers is a combination of mupirocin nasal ointment and disinfectant soap for 5 days, along with hygiene advice. If treatment fails, sources in the vicinity of the patient must be sought. Complicated carriers receive a combination of 2 oral antibiotics, in addition to mupirocin nasal ointment and disinfectant soap, for at least 7 days.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Carrier State
  • Drug Therapy, Combination
  • Evidence-Based Medicine
  • Humans
  • Hygiene*
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Mupirocin / therapeutic use*
  • Nasal Cavity / microbiology
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology*
  • Treatment Outcome

Substances

  • Mupirocin