Effects of GSM-modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells

Radiat Res. 2008 Dec;170(6):803-10. doi: 10.1667/RR1213.1.

Abstract

We examined the effects of in vivo exposure to a GSM-modulated 900 MHz RF field on the ability of bone marrow cells to differentiate, colonize lymphatic organs, and rescue lethally X-irradiated mice from death. X-irradiated mice were injected with medium alone or containing bone marrow cells from either RF-field-exposed (SAR 2 W/kg, 2 h/day, 5 days/ week, 4 weeks) or sham-exposed or cage control donor mice. Whereas all mice injected with medium alone died, mice that received bone marrow cells survived. Three and 6 weeks after bone marrow cell transplantation, no differences in thymus cellularity and in the frequencies of differentiating cell subpopulations (identified by CD4/CD8 expression) were observed among the three transplanted groups. Mitogen-induced thymocyte proliferation yielded comparable levels in all transplanted groups. As to the spleen, no effects of the RF-field exposure on cell number, percentages of B and T (CD4 and CD8) cells, B- and T-cell proliferation, and IFN-gamma production were found in transplanted mice. In conclusion, our results show no effect of in vivo exposure to GSM-modulated RF fields on the ability of bone marrow precursor cells to home and colonize lymphoid organs and differentiate in phenotypically and functionally mature T and B lymphocytes.

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / radiation effects
  • Bone Marrow Cells / metabolism
  • Bone Marrow Cells / radiation effects*
  • Bone Marrow Transplantation
  • Cell Count
  • Cell Differentiation / radiation effects
  • Cell Proliferation / radiation effects
  • Electromagnetic Fields*
  • Female
  • Mice
  • Radio Waves*
  • Spleen / cytology
  • Spleen / radiation effects
  • Survival Rate
  • T-Lymphocytes / cytology
  • T-Lymphocytes / radiation effects
  • Thymus Gland / cytology
  • Thymus Gland / radiation effects