Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity

Biomacromolecules. 2009 Feb 9;10(2):353-9. doi: 10.1021/bm801129y.


Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Bacteria / drug effects
  • Biocompatible Materials / chemistry
  • Carbohydrates
  • Hemolysis / drug effects*
  • Microbial Sensitivity Tests
  • Plastics / chemistry
  • Plastics / pharmacology*
  • Polyethylene
  • Static Electricity


  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Carbohydrates
  • Plastics
  • polynorbornen
  • Polyethylene