Hydroxychloroquine-induced hyperpigmentation: a case report

J Clin Pharm Ther. 2008 Dec;33(6):699-701. doi: 10.1111/j.1365-2710.2008.00955.x.


The antimalarials are one of the most commonly prescribed drugs in medical practice, for conditions such as rheumatoid arthritis as well as malaria. They are generally well-tolerated and the possible side effects of synthetic antimalarials, though infrequent, are well known. Besides the familiar adverse reactions, a localized mucocutaneous bluish-grey to black discolouration can sometimes be seen with antimalarial drugs. The aim of this report was to draw attention to the localized mucocutaneous bluish-grey hyperpigmentation induced by hydroxychloroquine with a case presentation and a review of the literature.

Publication types

  • Case Reports

MeSH terms

  • Antimalarials / adverse effects*
  • Female
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Hyperpigmentation / chemically induced*
  • Middle Aged
  • Sjogren's Syndrome / drug therapy


  • Antimalarials
  • Hydroxychloroquine