Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases

Nucleic Acids Res. 2009 Mar;37(4):1297-307. doi: 10.1093/nar/gkn1008. Epub 2009 Jan 12.


We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Variation*
  • Genomics / methods
  • Phosphoproteins / chemistry*
  • Phosphoproteins / classification
  • Phosphoproteins / genetics
  • Phosphorylation
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Sequence Analysis, Protein*
  • Software


  • Phosphoproteins
  • Protein Kinases