Abstract
The analysis of vine stem extract from MILLETTIA DIELSIANA Harms yielded a novel benzil ( 1) and five new prenylated isoflavones ( 2 - 6) together with three known isoflavones ( 7 - 10) and one known flavone ( 11), and their structures were elucidated on the basis of chemical and spectral analysis. The absolute configuration of the 3'',4''-diols in 6 was determined by observing the CD induced after addition of dimolybdenum tetraacetate in DMSO solution (Snatzke's method). Some isolates were tested for their anti-inflammatory and antithrombase activities and cytotoxicities. Compound 2, barbigerone, and genistein showed significant anti-inflammatory activity, with inhibitory ratios 59.1 %, 59.5 %, and 58.5 %, respectively, at 10 muM, while compound 4 exhibited moderate cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cell Line, Tumor
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification
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Cytotoxins / pharmacology*
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Fibrinolytic Agents / chemistry
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Fibrinolytic Agents / isolation & purification
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Fibrinolytic Agents / pharmacology*
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Flavones
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Flavonoids
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Glucuronidase / antagonists & inhibitors
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification
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Isoflavones / pharmacology*
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Millettia / chemistry*
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Molecular Structure
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Phenylglyoxal / analogs & derivatives*
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Phenylglyoxal / chemistry
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Phenylglyoxal / isolation & purification
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Phenylglyoxal / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Stems
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Rats
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Thrombin / antagonists & inhibitors
Substances
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Anti-Inflammatory Agents
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Cytotoxins
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Fibrinolytic Agents
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Flavones
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Flavonoids
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Isoflavones
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Plant Extracts
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Glucuronidase
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Thrombin
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Phenylglyoxal
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flavone
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benzil