Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Phytother Res. 2009 Sep;23(9):1197-204. doi: 10.1002/ptr.2761.


Vitis vinifera, known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as antioxidative, anti-inflammatory, and antimicrobial activities, as well as having cardioprotective, hepatoprotective, and neuroprotective effects. Thus, the present review attempts to give a short overview on the pharmacological, toxicological, and clinical studies of grape and its active components.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Anticarcinogenic Agents / pharmacology
  • Antioxidants / pharmacology
  • Cardiotonic Agents / pharmacology
  • Flavonoids / pharmacology*
  • Molecular Structure
  • Phytotherapy
  • Plant Extracts / pharmacology*
  • Stilbenes / pharmacology
  • Vitis / chemistry*


  • Anti-Infective Agents
  • Anticarcinogenic Agents
  • Antioxidants
  • Cardiotonic Agents
  • Flavonoids
  • Plant Extracts
  • Stilbenes