Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children

World J Gastroenterol. 2009 Jan 21;15(3):270-9. doi: 10.3748/wjg.15.270.


Inflammatory bowel disease is a chronic, debilitating disorder of the gastrointestinal tract. The etiology of inflammatory bowel disease has not been elucidated, but is thought to be multifactorial with both environ-mental and genetic influences. A large body of research has been conducted to elucidate the etiology of inflammatory bowel disease. This article reviews this literature, emphasizing the studies of breastfeeding and the studies of genetic factors, particularly NOD2 polymorphisms.

Publication types

  • Review

MeSH terms

  • Breast Feeding*
  • Contraceptives, Oral / adverse effects
  • Genetic Predisposition to Disease*
  • Humans
  • Inflammatory Bowel Diseases / epidemiology
  • Inflammatory Bowel Diseases / etiology*
  • Inflammatory Bowel Diseases / genetics*
  • Inflammatory Bowel Diseases / prevention & control
  • Meta-Analysis as Topic
  • Nod2 Signaling Adaptor Protein / genetics
  • Polymorphism, Genetic


  • Contraceptives, Oral
  • Nod2 Signaling Adaptor Protein