Thermodynamics of G x A mispairs in DNA: continuum electrostatic model

J Chem Phys. 2009 Jan 7;130(1):015101. doi: 10.1063/1.3050107.

Abstract

An analysis of the stability of a duplex containing G x A mispairs or G x A/A x G tandem during the DNA melting has shown that the duplex stability depends on both DNA sequences and the conformations of the G x A mispairs. The thermodynamics of single pair opening for the G(anti) x A(syn) and G(anti) x A(anti) conformations adopted by a G x A mispair is found to strongly correlate with that of the canonical base pairs, while for the sheared conformation a significant difference is observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine
  • Base Pair Mismatch*
  • DNA / chemistry*
  • Guanine
  • Models, Molecular*
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Static Electricity
  • Thermodynamics*

Substances

  • Guanine
  • DNA
  • Adenine