Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial

Digestion. 2008;78(4):224-8. doi: 10.1159/000190975. Epub 2009 Jan 13.


Purpose: To investigate the safety and efficacy of an extract of Ziziphus jujuba for chronic constipation.Constipated patients received liquid Z. jujuba or placebo for 12 weeks. Subjects completed questionnaires, a visual analog scale and transit time (TT) tests before and after treatment.

Results: Of 37 patients with a prolonged TT, 18 received the study drug and 19 a placebo. Two (12%) of the study and 16 (84%) of the control group dropped out due to severe constipation. The TT decreased from 12.2 particles for the study group to 3 particles at week 11. Symptom severity ratings decreased from 6 and 6.2 to 2 and 5, and the quality of life score improved from 1.9 and 2.3 to 1.3 and 1.4 in the study and control groups, respectively.

Conclusion: Z. jujuba extract is an effective and safe treatment for chronic constipation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Constipation / drug therapy*
  • Constipation / physiopathology
  • Double-Blind Method
  • Gastrointestinal Transit / drug effects
  • Humans
  • Middle Aged
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use*
  • Quality of Life
  • Severity of Illness Index
  • Treatment Outcome
  • Ziziphus / chemistry*


  • Plant Extracts