Using genetic data in cognitive neuroscience: from growing pains to genuine insights

Nat Rev Neurosci. 2008 Sep;9(9):710-20. doi: 10.1038/nrn2461.


Research that combines genetic and cognitive neuroscience data aims to elucidate the mechanisms that underlie human behaviour and experience by way of 'intermediate phenotypes': variations in brain function. Using neuroimaging and other methods, this approach is poised to make the transition from health-focused investigations to inquiries into cognitive, affective and social functions, including ones that do not readily lend themselves to animal models. The growing pains of this emerging field are evident, yet there are also reasons for a measured optimism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Behavior / physiology
  • Brain / anatomy & histology
  • Brain / physiology
  • Cognition / physiology*
  • Diagnostic Imaging
  • Humans
  • Molecular Biology*
  • Neural Pathways / physiology
  • Neurosciences / methods*
  • Neurosciences / trends*
  • Phenotype