Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia

Bull Exp Biol Med. 2008 Aug;146(2):218-22. doi: 10.1007/s10517-008-0259-3.
[Article in English, Russian]

Abstract

A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling.

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / therapeutic use
  • Arrhythmias, Cardiac / drug therapy
  • Cardiotonic Agents / therapeutic use*
  • Coronary Occlusion / physiopathology
  • Drug Combinations
  • Electrocardiography
  • Heart / drug effects
  • Heart / physiopathology
  • Malates / therapeutic use*
  • Male
  • Mitochondria, Heart / drug effects
  • Mitochondria, Heart / metabolism
  • Myocardial Ischemia / drug therapy*
  • Myocardial Ischemia / physiopathology
  • Oxidative Phosphorylation / drug effects
  • Rats
  • Rats, Wistar
  • Succinic Acid / therapeutic use*
  • Tachycardia / drug therapy
  • Trimetazidine / therapeutic use*
  • Vasodilator Agents / therapeutic use*

Substances

  • Anti-Arrhythmia Agents
  • Cardiotonic Agents
  • Drug Combinations
  • Malates
  • Vasodilator Agents
  • malic acid
  • Succinic Acid
  • Trimetazidine