Abstract
Antiamnesic activity of Noopept was studied on the original three-way model of conditioned passive avoidance response, which allows studying spatial component of memory. Cholinoceptor antagonists of both types (scopolamine and mecamylamine) decreased entry latency and reduced the probability for selection of the safe compartment. Noopept abolished the antiamnesic effect of cholinoceptor antagonists and improved spatial preference.
MeSH terms
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Animals
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Cholinergic Agonists / metabolism
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Cholinergic Agonists / pharmacology
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Cholinergic Antagonists / metabolism
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Cholinergic Antagonists / pharmacology
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Dipeptides / pharmacology*
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Male
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Mecamylamine / metabolism
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Mecamylamine / pharmacology
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Memory / drug effects*
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Memory Disorders / prevention & control*
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Nicotinic Antagonists / metabolism
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Nicotinic Antagonists / pharmacology
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Nootropic Agents / pharmacology*
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Rats
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Scopolamine / metabolism
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Scopolamine / pharmacology
Substances
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Cholinergic Agonists
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Cholinergic Antagonists
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Dipeptides
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Nicotinic Antagonists
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Nootropic Agents
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ethyl phenylacetyl-Pro-Gly
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Mecamylamine
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Scopolamine