Madura leg due to Exophiala jeanselmei successfully treated with surgery and itraconazole therapy

Med Mycol. 2009;47(6):648-52. doi: 10.1080/13693780802669194.


Exophiala jeanselmei, also known as Phialophora jeanselmei, is a dematiaceous fungus widely distributed in nature. The organism can cause cutaneous, subcutaneous or systemic infections. An uncommon clinical presentation is eumycetoma, i.e., a subcutaneous infection associated with draining sinuses releasing clumps or granules of the fungus. We describe a case of a long standing mycetoma with several draining sinuses involving the left lower leg of a 47-year-old Saudi Arab male. The disease required extensive surgical excision coupled with intense antifungal chemotherapy to achieve cure.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Exophiala / isolation & purification*
  • Humans
  • Immunohistochemistry
  • Itraconazole
  • Leg / microbiology*
  • Leg / pathology
  • Leg / surgery
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Mycetoma* / diagnosis
  • Mycetoma* / drug therapy
  • Mycetoma* / pathology
  • Mycetoma* / surgery
  • Saudi Arabia


  • Antifungal Agents
  • Itraconazole