Descending control of nociception: Specificity, recruitment and plasticity

Brain Res Rev. 2009 Apr;60(1):214-25. doi: 10.1016/j.brainresrev.2008.12.009. Epub 2008 Dec 25.


The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms. Descending control of spinal nociception originates from many brain regions and plays a critical role in determining the experience of both acute and chronic pain. The earlier concept of descending control as an "analgesia system" is now being replaced with a more nuanced model in which pain input is prioritized relative to other competing behavioral needs and homeostatic demands. Descending control arises from a number of supraspinal sites, including the midline periaqueductal gray-rostral ventromedial medulla (PAG-RVM) system, and the more lateral and caudal dorsal reticular nucleus (DRt) and ventrolateral medulla (VLM). Inhibitory control from the PAG-RVM system preferentially suppresses nociceptive inputs mediated by C-fibers, preserving sensory-discriminative information conveyed by more rapidly conducting A-fibers. Analysis of the circuitry within the RVM reveals that the neural basis for bidirectional control from the midline system is two populations of neurons, ON-cells and OFF-cells, that are differentially recruited by higher structures important in fear, illness and psychological stress to enhance or inhibit pain. Dynamic shifts in the balance between pain inhibiting and facilitating outflows from the brainstem play a role in setting the gain of nociceptive processing as dictated by behavioral priorities, but are also likely to contribute to pathological pain states.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Stem / anatomy & histology
  • Brain Stem / physiology*
  • Efferent Pathways / anatomy & histology
  • Efferent Pathways / physiology
  • Humans
  • Medulla Oblongata / cytology
  • Medulla Oblongata / physiology
  • Nerve Fibers, Unmyelinated / physiology
  • Neural Inhibition / physiology
  • Nociceptors / physiology*
  • Pain / physiopathology*
  • Posterior Horn Cells / physiology
  • Reticular Formation / cytology
  • Reticular Formation / physiology
  • Spinal Cord / anatomy & histology
  • Spinal Cord / physiology*