Apoptosis in animal models of virus-induced disease

Nat Rev Microbiol. 2009 Feb;7(2):144-55. doi: 10.1038/nrmicro2071.


Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Disease Models, Animal
  • Humans
  • Mice
  • Rats
  • Virus Diseases / metabolism*


  • Caspases